Why the study?
Little is known about the post-operative immune B cell compartment and the extent to which dysregulation in B cell pathways can be reversed following bariatric surgery.
Does bariatric surgery restore normal peripheral blood B cell profiles and inflammatory markers in individuals with obesity compared to lean controls?
Population
21 individuals with obesity (BMI at least 35 kg/m2) and 18 age- and sex-matched lean controls
Comparison
Pre- and post-bariatric surgery vs age- and sex-matched lean controls
Design
Prospective cohort study
Follow-up
6 months
Authors
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Bariatric surgery effects on B-cell immunity remain understudied; leaves open whether dysregulation reverses post-operatively.
Does bariatric surgery restore normal peripheral blood B cell profiles and inflammatory markers in individuals with obesity compared to lean controls?
Bariatric surgery restores some B cell populations but creates a unique immunometabolic state characterized by elevated inflammation-associated B cell subsets despite overall metabolic improvement.
Šlisere et al. (2023) studied this question.
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