Role of Single Dose Preoperative Ceftriaxone in the Control of Surgical Site Infection in a Tertiary Level Hospital

Mohammad Mushfiqur Rahman; Md Mazedur Rahman; Mamun Ibn Munim; Md. Shariful Haque

doi:10.3329/fmcj.v11i1.30869

December 29, 2016Faridpur Medical College JournalOpen Access

Role of Single Dose Preoperative Ceftriaxone in the Control of Surgical Site Infection in a Tertiary Level Hospital

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Why the study?

Does a single preoperative dose of ceftriaxone prevent surgical site infection as effectively as a prolonged postoperative antibiotic course in patients undergoing clean-contaminated elective laparotomy?

Structured PICO

Does a single preoperative dose of ceftriaxone prevent surgical site infection as effectively as a prolonged postoperative antibiotic course in patients undergoing clean-contaminated elective laparotomy?

P

Population

100 patients aged 18-60 years undergoing clean-contaminated elective laparotomy at a single tertiary hospital. Exclusions included diabetes mellitus, uraemia, immunosuppression, corticosteroid therapy, and BMI <18 or >25.

I

Intervention

Single dose preoperative intravenous ceftriaxone (1 gm) administered 30 minutes before induction of anaesthesia, with no postoperative antibiotics.

C

Comparator

Single dose preoperative intravenous ceftriaxone (1 gm) administered 30 minutes before induction of anaesthesia, followed by intravenous ceftriaxone for 2 days and then oral cefixime for the next 5 days.

O

Outcome

Surgical site infection assessed on the 3rd to 7th postoperative day on the basis of the ASEPSIS score.hard clinical

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Implication

A single preoperative dose of ceftriaxone is as effective as a prolonged postoperative antibiotic course for preventing surgical site infections in clean-contaminated elective laparotomies.

Abstract

Post-surgical wou infection is a crucial factor in surgical practice. Prolong use of postoperative antibiotic is common practice in our surgical world. This causes financial burden to our patients a antibiotic resistance. But international journals a literatures suggest using antibiotics as prophylaxis only at the time of operation a no further postoperative antibiotic is needed in clean contaminated surgery. This comparative cross-sectional study was done at the department of surgery, Sylhet MAG Osmani Medical College Hospital from 1st July 2007 to 30th June 2008. A total number of 100 patients of clean-contaminated elective laparotomy were selected. Patients were ra omly divided into two groups, in Group-I (got single dose preoperative Inj. Ceftriaxone) a in group-II (got single dose preoperative Inj. Ceftriaxone followed by Inj. Ceftriaxone for 2 days a then Cap. Cefxime for next 5 days). There is no statistically significant difference in outcome between two groups. So, single dose preoperative Inj. Ceftriaxone (1gm) is sufficient as a prophylaxis of surgical site infection in clean-contaminated elective surgery.Faridpur Med. Coll. J. Jan 2016;11(1): 6-10

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Cite This Study

Rahman et al. (2016) studied this question.

synapsesocial.com/papers/6a70c576e71d69abee08d53c https://doi.org/10.3329/fmcj.v11i1.30869

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Role of Single Dose Preoperative Ceftriaxone in the Control of Surgical Site Infection in a Tertiary Level Hospital

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

Role of Single Dose Preoperative Ceftriaxone in the Control of Surgical Site Infection in a Tertiary Level Hospital

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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