Computational modeling demonstrates that pathological abnormal excitation leads to spatiotemporal chaos, providing a mechanistic basis for the pro-arrhythmic effects of early afterdepolarizations.
Model results on excitation effects do not guide arrhythmia care; leaves open translation of spiral wave dynamics to clinical settings.
The effect of physiological and pathological abnormal excitation of a myocyte on the spiral waves is investigated based on the cellular automaton model. When the excitability of the medium is high enough, the physiological abnormal excitation causes the spiral wave to meander irregularly and slowly. When the excitability of the medium is low enough, the physiological abnormal excitation leads to a new stable spiral wave. On the other hand, the pathological abnormal excitation destroys the spiral wave and results in the spatiotemporal chaos, which agrees with the clinical conclusion that the early after depolarization is the pro-arrhythmic mechanism of some anti-arrhythmic drugs. The mechanisms underlying these phenomena are analyzed.
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Min-Yi et al. (2016) studied this question.
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