Population
Frog's skeletal muscle
Comparison
Hypertonic solutions vs Normal osmolality solutions
Design
Preclinical
Authors
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Does not support clinical changes; leaves open osmotic effects on mammalian cardiac muscle energetics.
Hypertonic solutions significantly increase the resting heat production of frog skeletal muscle, potentially due to calcium ion release increasing myosin ATPase activity.
Kazuhiro Yamada (1970) studied this question.
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