THE BIOCHEMICAL SOCIETY these compartments and, in the case of the peripheral and intracristal spaces, in the extent to which they are interconnected. The changes in the configuration of the inner membrane must be accompanied by alterations in the interaction of its subunits (whether it be cause or effect) and it is to be expected that this is accompanied by alterations in its properties. Thus Pollak & Munn (1969) ascribe the altered behaviour ofrat liver mitochondria on sucrose density gradients associated with the induction ofsteady state (State 4) to alterations in the permeability of the inner membrane to sucrose.
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Ernesto Carafoli (1970) studied this question.