Key result
T-cell subsets exert divergent effects in atherosclerosis, with Th1 driving and Treg limiting disease progression.
Atherosclerosis is a chronic inflammatory disease of the artery wall. Atherosclerotic lesions contain monocytes, macrophages, smooth muscle cells and T lymphocytes. Here, we review the role of T-lymphocyte subsets in atherosclerosis. Among CD4⁺T cells, T(h)1 cells are pro-atherogenic, T(reg) cells are athero-protective and the role of T(h)2 and T(h)17 cells remains unclear. The role of follicular helper T cells in atherosclerosis remains unknown, as is the role of CD8⁺T cells. NKT cells bind glycolipid antigens and exert a pro-atherogenic role. The antigen specificity of T-cell responses in atherosclerosis is poorly understood. In order to enable antigen-specific prevention or therapy, a better understanding of these mechanisms is needed.
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Tse et al. (2013) conducted a review in Atherosclerosis. T-lymphocyte subsets play distinct roles in atherosclerosis: Th1 and NKT cells are pro-atherogenic, Treg cells are athero-protective, and the roles of Th2, Th17, Tfh, and CD8+ T cells remain unclear.
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