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The vasodilatory drug nicotinic acid is still widely used in the treatment of tinnitus. Although neither the success rate of this drug nor the pharmacokinetic mechanism underlying the supposed suppressive effect on tinnitus is known, it is clear from the literature that the vasodilative effect is not responsible for its effect on tinnitus. In a double blind controlled trial performed in 48 patients, the value of the related drug nicotinamide was assessed and compared with the effect of a placebo. The results obtained with nicotinamide were not better than those observed for the placebo.
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Hulshof et al. (1987) studied this question.
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