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The plasma clearance and consumption of I131 labeled insulin was determined in normal, nephrectomized and splanchnicectomized rabbits. The rate constant for plasma disappearance of labeled material was decreased by nephrectomy but not by splanchnicectomy. The plasma clearance of insulin was decreased by splanchnicectomy but the remaining renal circulation was able to maintain the consumption rate of insulin at a normal level.
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Palmer et al. (1961) studied this question.
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