Why the study?
Does enalapril or SC-51316 reduce chemoattractant and adhesion molecule synthesis in rats with unilateral ureteral obstruction?
Population
Rats with unilateral ureteral obstruction (UUO) of 1, 3, or 5 days duration
Comparison
Enalapril or SC-51316 administered in drinking… vs Untreated rats with unilateral ureteral…
Design
Preclinical
Follow-up
1, 3, or 5 days
Authors
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Enalapril attenuates VCAM-1 in rat ureteral obstruction unlike AT1 blockade; hypothesis-generating for differential anti-inflammatory effects in human renal disease.
Does enalapril or SC-51316 reduce chemoattractant and adhesion molecule synthesis in rats with unilateral ureteral obstruction?
ACE inhibition with enalapril, but not AT1 receptor antagonism with SC-51316, blunts VCAM-1 expression in a rat model of ureteral obstruction, potentially explaining differential effects on macrophage infiltration.
Morrissey et al. (1998) studied this question.
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