Scalable Electrochemical Dehydrogenative Lactonization of C(sp²/sp³)–H Bonds

A practical, electrochemical method is developed for the direct dehydrogenative lactonization of C(sp 2 /sp 3 )–H bonds under external oxidant- and metal-free conditions, delivering diverse lactones, including coumarin derivatives with excellent regioselectivity. The scalable nature of this newly developed electrochemical process was demonstrated on a 40 g scale following an operationally simple protocol. The remote lactonization of C(sp 3 )–H bonds would constitute an important synthetic advance toward electrochemical C–O bond formation.