Answers are grounded in this paper and cite their sources.
Comparison of the effects of MTU and T4 withdrawal on different thyroid parameters has been made in the rat. After the withdrawal of chronic MTU treatment, marked rebound in thyroidal 131I uptake and conversion ratio was produced but not in thyroid weight, while no rebound was produced in any of thyroid parameters after a single injection of MTU. After a single injection of T4, however, pronounced rebound was produced in thyroidal 131I uptake, conversion ratio and thyroid weight.A similar type of rebound of neurosecretory substance was also produced after the withdrawal of chronic MTU treatment.It is postulated that the difference in the response of thyroid weight might be related to different pattern of circulating TSH. Possible participation of hypothalamic neurosecretory system for the production of rebound phenomena is discussed.
No takes yet. Share an insight, caveat, or question.
Shin-Ichi Shimoda (1960) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: