Studies on Two Patients with Concomitant Pernicious Anemia and Immunoglobulin Deficiency

Case Studies1 August 1967Studies on Two Patients with Concomitant Pernicious Anemia and Immunoglobulin DeficiencyROBERT CLARK, KARL TORNYOS, M.D., VICTOR HERBERT, M.D., JEREMIAH J. TWOMEYROBERT CLARKSearch for more papers by this author, KARL TORNYOS, M.D.Search for more papers by this author, VICTOR HERBERT, M.D.Search for more papers by this author, JEREMIAH J. TWOMEYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-403 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical and immunological association between the adult type of pernicious anemia and thyroid disorders has been the subject of recent reviews (1-6). Up to 90% of patients who have pernicious anemia demonstrate serum antibodies against parietal cell antigens, up to 60% against intrinsic factor, and more than 50% against thyroid antigens. The reported prevalence of these serum antibodies varies with different techniques. This prevalence greatly exceeds that found in a control population (2, 7). Parietal cell antibodies have also been associated with cells of gastric biopsies obtained from patients who have pernicious anemia (8). These observations and the prominence...References1. TAYLOR KB: Immune phenomena in pernicious anemia. Gastroenterology 45: 670, 1963. CrossrefMedlineGoogle Scholar2. DONIACHROITT DIM: An evaluation of gastric and thyroid auto-immunity in relation to hematologic disorders. Seminars Hemat. 1: 313, 1964. MedlineGoogle Scholar3. HERBERT V: Immunologic factors in pernicious anemia. Postgrad. Med. In press. Google Scholar4. ROITTDONIACHSHAPLAND IMDC: Auto-immunity in pernicious anemia and atrophic gastritis. Ann. N. Y. Acad. Sci. 124: 664, 1965. Google Scholar5. IRVINE WJ: Immunologic aspects of pernicious anemia. New Eng. J. Med. 273: 432, 1965. CrossrefMedlineGoogle Scholar6. 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Author, Article, and Disclosure InformationAffiliations: From the Departments of Internal Medicine, William Beaumont General Hospital, El Paso, Tex., Veterans Administration Hospital and Baylor University College of Medicine, Houston, Tex., and The Mount Sinai Hospital and School of Medicine, New York, N. Y.This study was supported by grants AM 09564 and AM 09062, the U. S. Public Health Service, Washington, D. C., and by the Research and Development Service, William Beaumont General Hospital.Requests for reprints should be addressed to Jeremiah J. Twomey, M.B., Chief, Hematology Service, Veterans Administration HospitalHouston, Tex. 77031. 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CONN, M.D., HENRY BINDER, M.D., BRANTLEY BURNS, M.D.Absorption of Vitamin B12 and Folic AcidCorrectable Intestinal Defect of Vitamin B12 Absorption in Pernicious AnemiaRALPH CARMEL, M.D., VICTOR HERBERT, M.D. 1 August 1967Volume 67, Issue 2Page: 403-410KeywordsAntibodiesAntigensBiopsyClinical immunologyHospital medicineMedical servicesParietal cellsPernicious anemiaThyroidThyroid diseases Issue Published: 1 August 1967 PDF DownloadLoading ...