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June 1, 1992AJP Cell Physiology

Heptanol produced a dose-dependent decrease in junctional current (dissociation constant = 0.54 and 1.20 mM for whole cell and perforated patch experiments, respectively) and reduced nonjunctional currents, likely by decreasing the open probability of gap junction channels via lipid membrane structure alteration.

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Population

Cultured neonatal rat heart cells (monolayer cultures)

Comparison

Exposure to heptanol vs Control conditions (no heptanol)

Design

Preclinical

Authors

BTBrenda R. Takens-KwakAmsterdam UMC Location University of AmsterdamHJHabo J. JongsmaCentre National de la Recherche ScientifiqueMRMartin B. RookElectrophysiology

Discussion

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Overview

Animal data indicate heptanol reversibly uncouples cardiac gap junctions via membrane lipids; leaves open in vivo specificity and therapeutic translation.

Structured PICO

P
Population
Cultured neonatal rat heart cells (monolayer cultures)
I
Intervention
Exposure to heptanol
C
Comparator
Control conditions (no heptanol)
O
Outcome
Gap junctional and non-junctional membrane currents, single-channel conductances, and fluorescence steady-state anisotropysurrogate

Heptanol induces reversible uncoupling of cardiac gap junctions by altering lipid membrane structure and decreasing the open probability of gap junction channels, rather than acting specifically on the channels themselves.

Cite This Study

Takens-Kwak et al. (1992) studied this question.

synapsesocial.com/papers/6a70d4e5fe4101aa97e05488https://doi.org/10.1152/ajpcell.1992.262.6.c1531
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