Why the study?
Extensive research is required to provide better management and treatment strategies for von Willebrand disease, an inherited bleeding disorder that can be life-threatening.
This narrative review provides a comprehensive overview of the classification, symptoms, diagnosis, and treatment strategies for Von Willebrand Disease.
VWD review reinforces core mechanisms; leaves open need for updated management trials.
Von Willebrand Disease (VWD) is a disorder of blood in which the proper clotting of the blood does not occur. Von Willebrand Factor (VMF) is an important multimeric glycoprotein of the blood that helps to stop the bleeding. When the function of this von Willebrand factor is impaired we can observe this Von Willebrand Disease. Usually, the VWF in the blood attaches to small blood cells called platelets when a person is injured and starts to bleed. In order to stop bleeding at the site of injury, this VWF helps the platelets stick together to form a clot by acting like a glue. In case of the patients with Von Willebrand Disease it is very difficult to stop the bleeding and is often life threatening. In this review, the symptoms, diagnosis and the treatment strategies were discussed. Health care professionals expertise in the haemostasis are required in the clinical scenario for better management of this disease. As it is an inherited disease, special care must be taken in evaluating the family history during the diagnosis and extensive research is still required for providing the better management and treatment.
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Hima Bindu Mylapalli (2021) studied this question.