Why the study?
Does ACE gene I/D polymorphism increase susceptibility to psoriasis and elevate serum IL-6 and IL-8 levels?
Does ACE gene I/D polymorphism increase susceptibility to psoriasis and elevate serum IL-6 and IL-8 levels?
The ACE D allele is associated with increased susceptibility to psoriasis and elevated serum levels of pro-inflammatory cytokines IL-6 and IL-8.
ACE D allele linked to higher IL-6/IL-8 and psoriasis risk in case-control data; leaves open causal role and any diagnostic utility.
BACKGROUND: Psoriasis is a chronic, recurrent inflammatory skin disease. It is characterised by autoimmune, environmental factors and complex genetic disorder.AIM: To explore the role of IL-6, IL-8, and ACE I/D polymorphism in the pathogenesis of Psoriasis and investigation of the relationship between ACE polymorphism and occurrence of psoriasis.PATIENTS AND METHODS: In this study, we took 73 psoriasis patients and 47 healthy patients as a control. These two groups subjected to analysis for ACE gene I/D polymorphism by PCR and biochemical methods.RESULTS: The serum levels of ACE, IL-8 and IL-6 were statistically significantly higher in psoriasis patients compared to healthy subjects (P < 0.001). ID and DD polymorphism were more common in psoriasis patients than healthy subjects. Also, D allele was significantly over-represented in patients compared to controls (52.7% Vs 35.1%).CONCLUSION: ACE gene polymorphism might grant susceptibility to develop psoriasis.
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Elneam et al. (2018) studied this question.
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