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May 26, 2000Circulation ResearchOpen Access

Immunoneutralization of Glycoprotein Ibα Attenuates Endotoxin-Induced Interactions of Platelets and Leukocytes With Rat Venular Endothelium In Vivo

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Why the study?

Does immunoneutralization of GP Ibalpha or P-selectin attenuate endotoxin-induced interactions of platelets and leukocytes with venular endothelium in vivo?

Population

Rat mesenteric venules in vivo model, isolated rat platelets, and isolated human platelets

Comparison

Anti-human glycoprotein Ibalpha monoclonal… vs Endotoxin administration without antibody…

Design

Preclinical

Authors

TKTomihiro KatayamaJapan Tobacco (United States)YIYasuo IkedaOtsuka (Japan)MHMakoto HandaKanazawa University

Discussion

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Implication

Supports GP Ibα/P-selectin role in endotoxin-induced rolling; leaves open translation to human sepsis management.

Structured PICO

Does immunoneutralization of GP Ibalpha or P-selectin attenuate endotoxin-induced interactions of platelets and leukocytes with venular endothelium in vivo?

P
Population
Rat mesenteric venules in vivo model, isolated rat platelets, and isolated human platelets
I
Intervention
Anti-human glycoprotein (GP) Ibalpha monoclonal antibody GUR83/35 or anti-rat P-selectin monoclonal antibody s789G
C
Comparator
Endotoxin administration without antibody treatment
O
Outcome
Platelet and leukocyte rolling velocities and interactions with venular endotheliumsurrogate

This study provides the first in vivo evidence that glycoprotein Ibalpha is involved in endotoxin-induced microvascular rolling of platelets and leukocytes.

Cite This Study

Katayama et al. (2000) studied this question.

synapsesocial.com/papers/6a70dca1febe604dd709a203https://doi.org/10.1161/01.res.86.10.1031
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased Neutrophil-Platelet Adhesion in Patients With Unstable Angina1996 · 403 citations
  2. 2Additional glycoprotein defects in Bernard-Soulier's syndrome: confirmation of genetic basis by parental analysis1983 · 180 citations
  3. 3The Glycoprotein Ib-IX-V Complex Is a Platelet Counterreceptor for P-Selectin1999 · 353 citations
  4. 4Mechanisms Initiating Platelet Thrombus Formation1997 · 372 citations
  5. 5The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.1991 · 616 citations