Editorial: Molecular mechanism and pharmacology of metabolism and cardiac remodeling

The progress of Heart failure (HF) is associated with insufficient energy, substrate utilization disorders, and oxidative stress. In cardiac injuries, metabolic remodeling often precedes most changes (1). The research topic encompasses studies related to cardiac immunometabolism, mitochondrial metabolism, molecular biomarkers, special case report and drug development and treatment for heart failure.Deviant mitophagy has been proved to induce energy metabolism dysfunction in the course of cardiac pathological events (2). Zhou et al. discovered that mesaconine, a major cardiotonic component of Fuzi, significantly rescued cardiac dysfunction and impaired mitophagy in cardiomyocytes of mice administered doxorubicin. Furthermore, the role of mesaconine is mediated by the activation of PINK1-induced mitophagy. These results hold substantial significance for the development of clinical trials with mesaconine. Through pharmacology experiments in rhesus monkeys and rats, Zhang et al. demonstrated beneficial effects of QiShenYiQi Dripping Pills (QSYQ) on HF, which may be associated with pathways involved in myocardial energy metabolism. It was the first report that identified n-3 PUFA protected the heart by modulating the APLNRdependent PI3K-AKT-mTOR signaling axis in the IR heart. These findings were further evidence that n-3 PUFA can protect mitochondrial structure and function. Previous studies have found a correlation between abnormal lipid metabolism and the progression of atrial fibrillation (AF) (4).Utilizing ultra-high-performance lipidomics analysis, Huang et al. determined that phosphatidylethanolamine (PE) was correlated with AF. Further，they identified that PE may exacerbate Ang II-induced atrial fibrosis through inducing mitochondrial damage and ferroptosis in cardiomyocytes. This study suggested that inhibiting PE and ferroptosis may be a promising therapeutic strategy for AF.Zou et al. presented a case report of idiopathic hypereosinophilic syndrome (IHES) complicated with intracardiac thrombus，which is a rare cardiac complication of HIS. Based on this case, novel oral anticoagulant (NOAC) therapy may be an effective option. This case contributed to a better comprehension of the pathology and cardiac complications of IHES.In conclusion, the "Molecular Mechanism and Pharmacology of Metabolism and Cardiac Remodeling" Research Topic focuses on recent insights into the molecular mechanism and pharmacology in cardiac metabolic remodeling and novel therapeutic targets for cardiac remodeling and heart failure.