Why the study?
Cardiovascular magnetic resonance has emerged as a non-invasive imaging modality for pediatric pulmonary hypertension, prompting an update on novel concepts and imaging biomarkers providing diagnostic, therapeutic, and prognostic information.
CMR is a valuable non-invasive imaging modality that provides comprehensive evaluation and novel biomarkers for pediatric pulmonary hypertension.
Cardiac catheterization remains key for pediatric PH risk stratification; leaves open validated noninvasive alternatives in this Level 5 review.
Pulmonary hypertension (PH) in children is a heterogenous disease of the small pulmonary arteries characterized by a progressive increase in pulmonary vascular resistance. Despite adequate medical therapy, long-term pressure overload is frequently associated with a progressive course leading to right ventricular failure and ultimately death. Invasive hemodynamic assessment by cardiac catheterization is crucial for initial diagnosis, risk stratification and therapeutic strategy. Although echocardiography remains the most important imaging modality for the assessment of right ventricular function and pulmonary hemodynamics, cardiovascular magnetic resonance (CMR) has emerged as a valuable non-invasive imaging technique that enables comprehensive evaluation of biventricular performance, blood flow, morphology and the myocardial tissue. In this review, we summarize the principles and applications of CMR in the evaluation of pediatric PH patients and present an update about novel CMR based concepts and imaging biomarkers that may provide further diagnostic, therapeutic and prognostic information.
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Latus et al. (2021) studied this question.
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