Clinical study demonstrates that tranexamic acid reduces blood loss and endometrial fibrinolytic enzymes in dysfunctional uterine bleeding, indicating a local mechanism of action.
Key Points
To determine the effect of tranexamic acid on measured menstrual blood loss and endometrial fibrinolytic enzyme activity in women with dysfunctional uterine bleeding.
Assessed women with dysfunctional uterine bleeding defined as menstrual blood loss exceeding 80 ml per cycle.
Obtained endometrial biopsies 24 to 36 hours following menstrual onset to quantify plasminogen conversion to plasmin via chromogenic assay and measure antigen concentrations using ELISA.
Tranexamic acid significantly reduced measured menstrual blood loss by 58% (p < 0.05).
Endometrial tissue plasminogen activator activity, tissue plasminogen activator antigen, and plasminogen activator inhibitor-type 1 antigen levels were significantly decreased following treatment.