Why the study?
This study aimed to evaluate risk factors associated with untreated hypertension and develop and internally validate an untreated risk nomogram for hypertensive patients in primary health care of less developed Northwest China.
A predictive nomogram incorporating demographic and socioeconomic factors can accurately identify hypertensive patients at high risk of remaining untreated in less developed regions of Northwest China.
Nomograms may aid targeting untreated hypertension in Northwest China primary care; leaves open need for external validation before adoption.
BACKGROUND: This study aims to evaluate the risk factors associated with untreated hypertension and develop and internally validate untreated risk nomograms in patients with hypertension among primary health care of less developed Northwest China. METHODS: = 269). Untreated hypertension was defined as not taking antihypertensive medication during the past two weeks. Using least absolute shrinkage and selection operator (LASSO) regression model, we identified the optimized risk factors of nontreatment, followed by establishment of a prediction nomogram. The discriminative ability, calibration, and clinical usefulness were determined using the area under the receiver operating characteristic curve (AUC), calibration curve, and decision analysis. The results were assessed by internal validation in the validation set. RESULTS: Five independent risk factors were derived from LASSO regression model and entered into the nomogram: age, herdsman, family income per member, altitude of habitation, and comorbidity. The nomogram displayed a robust discrimination with an AUC of 0.859 (95% confidence interval: 0.812-0.906) and good calibration. The nomogram was clinically useful when the intervention was decided at the untreated possibility threshold of 7% to 91% in the decision curve analysis. Results were confirmed by internal validation. CONCLUSIONS: Our nomogram showed favorable predictive accuracy for untreated hypertension in primary health care of less developed Northwest China and might help primary health care assess the risk of nontreatment in patients with hypertension.
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Wang et al. (2021) studied this question.
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