Key result
Adrenalectomy restores contralateral renal pressor content and lowers blood pressure in hypertensive rats.
In rats, clamping of one renal artery or encapsulation of one kidney leads to a significant decrease in pressor material (renin ?) in the contralateral “untouched” kidney, while in the clamped kidney pressor activity is normal or only slightly enhanced. 2. These changes in content of renal pressor material are not necessarily accompanied by increase in blood pressure but were observed in every case of renal hypertension. 3. When hypertensive rats were adrenalectomized and maintained on small doses of cortisol, there followed a decrease in blood pressure and restoration of level of pressor material in the unclamped kidney. 4. It is suggested that diminution of pressor material in the unclamped kidney is not a prerequisite but a consequence of the pathological situation leading to renal hypertension.
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Gross et al. (1958) studied Renal hypertension. Unilateral renal artery clamping or kidney encapsulation, followed by adrenalectomy with cortisol maintenance vs. Contralateral untouched kidney / intact adrenals was evaluated on Renal pressor material content and blood pressure. Unilateral renal artery clamping or kidney encapsulation in rats significantly decreased pressor material in the untouched kidney, which was restored along with reduced BP after adrenalectomy.
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