November 19, 2012Hematology ReportsOpen Access

Deep Vein Thrombosis, Ecythyma Gangrenosum and Heparin-Induced Thrombocytopenia Occurring in a Man with a Heterozygous Factor V Leiden Mutation

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Population

1 man heterozygous for the Factor V Leiden (FVL) mutation with a history of recurrent deep venous thrombosis

Design

Case_report

Authors

MAMariya Apostolova BWBaoying Weng HPHarry H. Pote

Discussion

Member takes

Implication

Requires vigilance for HIT and ecthyma gangrenosum in necrotic limbs on heparin; leaves open prospective study of thrombophilia interactions.

Structured PICO

Population

1 man heterozygous for the Factor V Leiden (FVL) mutation with a history of recurrent deep venous thrombosis

Intervention

Warfarin therapy, subsequently replaced by intravenous heparin, and then argatroban

Outcome

Development of skin necrosis, limb gangrene, and thrombocytopeniasafety

This case highlights the complex differential diagnosis of skin necrosis and limb gangrene in patients on anticoagulation, particularly those with underlying thrombophilia like Factor V Leiden.

Cite This Study

Apostolova et al. (2012) studied this question.

synapsesocial.com/papers/6a70e52ee36a167817e2b962 https://doi.org/10.4081/hr.2012.e20

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Implication

Requires vigilance for HIT and ecthyma gangrenosum in necrotic limbs on heparin; leaves open prospective study of thrombophilia interactions.

Deep Vein Thrombosis, Ecythyma Gangrenosum and Heparin-Induced Thrombocytopenia Occurring in a Man with a Heterozygous Factor V Leiden Mutation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Deep Vein Thrombosis, Ecythyma Gangrenosum and Heparin-Induced Thrombocytopenia Occurring in a Man with a Heterozygous Factor V Leiden Mutation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider