Key result
Novel anti-IL-8 antibodies cause recurrent heparin-induced thrombocytopenia despite repeatedly negative standard assays.
Case Report (n=1)
Platelet factor 4 heparin enzyme immunoassay, platelet aggregation test, and serotonin release assay are commonly used to diagnose and confirm heparin-induced thrombocytopenia. We describe a case of recurrent thrombocytopenia appearing in a few hours after each heparin administration and who tested negative for the three assays. Further analysis revealed anti-interleukin (IL)-8 antibodies and IL-8-dependent platelet activation facilitated by heparin, which may explain this unusual case of heparin-induced thrombocytopenia.
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Bounameaux et al. (2007) conducted a case report in Heparin-induced thrombocytopenia in antiphospholipid syndrome (n=1). Heparin administration was evaluated on IL-8-dependent platelet activation and anti-IL-8 antibodies. Heparin exposure in 1 patient with antiphospholipid syndrome caused recurrent thrombocytopenia mediated by anti-IL-8 antibodies despite 3 negative standard HIT assays.
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