The reaction rate of Knoevenagel condensation can be dramatically enhanced by irradiating the reaction mixture containing ethyl cyanoacetate, an aldehyde, P2O5, piperidine, and chlorobenzene with a commercial microwave oven. A number of Knoevenagel condensation products were prepared in good yields in very short reaction times (2-15min) under the microwave irradiation.
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Kim et al. (1997) studied this question.
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