Pharmacogenomics and new therapeutic choices are transforming anticoagulation therapy from a challenging process to a more precise and reliable routine.
Pharmacogenomic guidance enables safer routine coumarin dosing; confirms RCT utility of genetic markers for personalized anticoagulation.
What once was a nightmare for treating clinicians (dosing patients with coumarins, due to fear of severe and often life-threatening bleeding) may soon become a gratifying routine, with the availability of both, several therapeutic choices (already available), and reliable genetic and epigenetic markers to guide therapy selection with the necessary precision.
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Ragia et al. (2019) studied this question.
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