n engl j med 372;16 nejm.org april 16, 2015 1575 substantially among studies. Which cells and mechanisms are key is uncertain. In addition to the work that Munder and Tummler referenced, other research has not detected defects in myeloid cells.3-5 As we stated in our article, we focused “primarily on the newborn period, because this time window is key to discovering the origins of cystic fibrosis airway disease.” Myeloid cells from humans or animals with chronic infection, inflammation, or both might have altered function. Perhaps that explains, at least in part, why results vary among studies. David A. Stoltz, M.D., Ph.D. David K. Meyerholz, D.V.M., Ph.D. Michael J. Welsh, M.D.
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Pankow et al. (2015) studied this question.