Treatment of Subacute Bacterial Endocarditis

Article1 September 1954TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITISPAUL A. BUNN, M.D., ELLEN T. COOK, M.D.PAUL A. BUNN, M.D.Search for more papers by this author, ELLEN T. COOK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-3-487 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSubacute bacterial endocarditis has been treated with reasonable success for nine years. The number of recoveries from this formerly universally fatal infection is a most gratifying experience in medicine and the therapeutic achievement is attributable directly to the antimicrobial efficacy of penicillin. In general, most studies indicate that approximately 70 per cent of all patients treated for the infection recover, although there is a considerable discrepancy in mortality rates among individual reports.1-5One perplexing feature of specific antimicrobial treatment, quite apparent lately, is the lack of a recent decrease in the mortality rate from the 30 per cent to 35...Bibliography1. BloomfieldArmstrongKirby ALCDWM: Treatment of subacute bacterial endocarditis with penicillin, J. Clin. Investigation 24: 251-267 (May) 1945. CrossrefMedlineGoogle Scholar2. DowlingMurray HFFJ: Incidence and cost of treatment of bacterial endocarditis, Am. J. M. Sc. 221: 612-618 (June) 1951. CrossrefMedlineGoogle Scholar3. GoslenFavourEmery RCBJ: Long-term follow-up study of penicillin treated cases of subacute bacterial endocarditis, New England J. Med. 242: 995-1001 (June 29) 1950. CrossrefMedlineGoogle Scholar4. Friedburg CK: Subacute bacterial endocarditis: revision of diagnostic criteria and therapy, J. A. M. A. 144: 527-533 (Oct. 14) 1950. CrossrefMedlineGoogle Scholar5. LittmanSchaaf DRS: Therapeutic experiences with subacute bacterial endocarditis with special references to failure, New England J. Med. 243: 248-252 (Aug. 17) 1950. CrossrefMedlineGoogle Scholar6. Hunter TM: Bacterial infections of heart and pericardium, Bull. New York Acad. Med. 28: 213-228 (Apr.) 1952. MedlineGoogle Scholar7. LevensonGriffithPearson DCGCHE: Increasing bacterial resistance to the antibiotics, Circulation 2: 668-675 (Nov.) 1950. CrossrefMedlineGoogle Scholar8. Mathews H: After history of successfully treated cases of subacute bacterial endocarditis, Brit. M. J. 2: 436-439 (Aug. 19) 1950. CrossrefMedlineGoogle Scholar9. Blumer G: Subacute bacterial endocarditis, Medicine 2: 105-170 (May) 1923. CrossrefGoogle Scholar10. KaneFenn LLJJ: Treatment of subacute bacterial endocarditis with Aureomycin and Chloromycetin, New England J. Med. 244: 623-628 (Apr. 26) 1951. CrossrefMedlineGoogle Scholar11. RobbinsTompsett WCR: Treatment of enterococcal endocarditis and bacteremia, Am. J. Med. 10: 287-299 (Mar.) 1951. CrossrefGoogle Scholar12. Fisher AM: Method for determination of antibacterial potency of serum during therapy of acute infections, Bull. Johns Hopkins Hosp. 90: 313-320 (Apr.) 1952. Google Scholar13. LoeweCandelEiber LSHB: Treatment of subacute enterococcus endocarditis, Ann. Int. Med. 34: 717-735 (Mar.) 1951. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL A. BUNN, M.D.; ELLEN T. COOK, M.D.Affiliations: Syracuse, New York*Received for publication January 11, 1954.Portions of this study have been supported by a grant from Bristol Laboratories, Inc., Syracuse, New York.From the Medical Department, State University of New York, Medical School at Syracuse, N. Y.†With the technical assistance of Leonard Canarilli.‡Permission to use private patients in this series was granted by Dr. E. C. Reifenstein, Dr. F. Geiger, Dr. J. G. F. Hiss, Dr. W. Pennock, Dr. R. D. Johnson, Dr. S. T. Killian, Dr. J. D. Ayer, Dr. G. B. Andrews, Dr. H. A. Feldman, Dr. E. G. Allen and Dr. J. J. Hogan.§Under the direction of Dr. O. D. Chapman. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGlomerulonephritis in bacterial endocarditisInfective Endocarditis in the Antibiotic EraBacterial endocarditisErkrankungen des EndokardContinuous intramuscular-drip penicillin therapy in bacterial endocarditisAntimicrobial Therapy in Cardiovascular InfectionsEmergence of Antibiotic-Resistant Bacteria 1 September 1954Volume 41, Issue 3 Page: 487-500 Keywords Antimicrobials Death rates Endocarditis Penicillin ePublished: 1 December 2008 Issue Published: 1 September 1954 PDF downloadLoading ...