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New ionization methods combined with powerful analyzers, detectors, and data systems have made mass spectrometry a versatile tool for molecular analysis. Samples consisting of nanogram quantities of hundreds of unique components are routinely analyzed. In favorable cases samples as small as 2.5 x 10(-14) gram and samples with masses of more than 3000 atomic mass units have been successfully examined.
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Woodfin V. Ligon (1979) studied this question.
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