Why the study?
Do cholesterol sulfate-containing liposomes efficiently entrap adriamycin and reduce leakage compared to sulfatide-containing liposomes?
Do cholesterol sulfate-containing liposomes efficiently entrap adriamycin and reduce leakage compared to sulfatide-containing liposomes?
Cholesterol sulfate is a useful and safe substitute for sulfatide in the preparation of negatively charged liposomes for adriamycin delivery.
CholSO4 liposomes merit further preclinical evaluation for ADM delivery; leaves open clinical translation and human safety data.
Cholesterol sulfate (CholSO4) was found to be a useful substitute of sulfatide for the preparation of negatively charged liposomes entrapping adriamycin (ADM). Liposomes composed of egg phosphatidylcholine, cholesterol, and CholSO4 in a molar ratio of 6:3:1 entrapped ADM efficiently and reduced the leakage of the entrapped ADM from the liposomes to the same degree as found for sulfatide-containing liposomes. The novel liposomes induced neither haemolysis nor platelet aggregation
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Noda et al. (1991) studied this question.
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