Do knot FRET: Single-molecule FRET was used to analyze the folding of human telomerase RNA (see scheme) and allowed discrimination between the correctly folded (left) and misfolded (right) structures. Analyzing the effects of various mutations showed that base pairing, triplex formation, and Mg2+ ion binding act synergistically in the folding of the pseudoknot structure in a functional hTR construct.
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Hengesbach et al. (2012) studied this question.
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