Coxsackievirus A 16 was identified as the pathogen in a 1970 Hand, Foot and Mouth Disease epidemic in Nobeoka city, with high isolation rates achieved using vesicle fluids and epidermis.
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Supports Coxsackie A16 etiology via vesicle isolation; leaves open relevance to modern diagnostics and surveillance.
During the summer of 1970, an epidemic of Hand, Foot and Mouth Disease was observed in Nobeoka city and its vicinity. Virological studies were performed on feces, rectal swabs, pharyngeal swabs and vesicle fluids of the skin obtained from 21 patients who visited the hospital on June 11.Virus isolations were positive on 17 patients' materials by means of inoculation into either suckling mice or primary cultures of monkey kidney cells. All the viruses isolated were proved to be Coxsackievirus A 16 by neutralization- test. In the present study, strains of Coxsackievirus A 16 could be isolated from 10 out of 13 vesicles.The use of both the epidermis of the vesicles and the vesicle fluids seems to have contributed to -this high isolation rate. Discussions were also made on the doubtful pathogenecity of allegedly pathogenic viruses other than Al 6 and, at the same time, the emphasis was laid on the importance of virus isolation from the vesicles.
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Mori et al. (1971) studied this question.
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