Why the study?
Immediate-release carvedilol requires twice-daily dosing and may have low treatment compliance, prompting evaluation of a once-daily extended-release formulation in patients with hypertension.
Does once-daily extended-release carvedilol reduce systolic blood pressure in patients with untreated or uncontrolled hypertension?
Population
134 patients with untreated or uncontrolled hypertension
Comparison
Low-dose carvedilol ER vs high-dose carvedilol ER vs placebo
Design
Double-blind, randomized, placebo-controlled trial
Follow-up
8 weeks
Authors
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Carvedilol ER failed to lower office SBP or DBP versus placebo; leaves open questions on optimal dosing or formulation for once-daily use.
Does once-daily extended-release carvedilol reduce systolic blood pressure in patients with untreated or uncontrolled hypertension?
Extended-release carvedilol did not result in a greater reduction in either SBP or DBP compared with placebo in patients with hypertension.
Wang et al. (2021) studied this question.