Why the study?
Few studies have characterized the minerals formed in cardiovascular cell culture models using physico-chemical methods or compared them to minerals produced by bone cells in culture.
Electron microscopy reveals that vascular smooth muscle cells form calcified nodules with elemental composition similar to bone but distinct morphology, providing mechanistic insights into cardiovascular soft tissue mineralization.
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In vitro valve cell models extend mechanistic insights into mineralization; leaves open clinical translation for aortic stenosis.
Tsolaki et al. (2019) studied this question.
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