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October 13, 2021Open Access

Bioinformatics-based Identification of the Mechanism Whereby Astragalus Membranaceus Inhibits Inflammation and Autophagy in Lupus Nephritis

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Population

Lupus nephritis targets and Astragalus membranaceus targets derived from the TCMSP database and WGCNA analysis

Design

Preclinical

Authors

TLTing LiuXQXiaomei QiaoKKKaili Kong

Discussion

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Overview

May identify candidate targets and pathways for Astragalus in LN; leaves open clinical relevance pending validation.

Structured PICO

P
Population
Lupus nephritis (LN) targets and Astragalus membranaceus targets derived from the TCMSP database and WGCNA analysis
I
Intervention
Astragalus membranaceus
O
Outcome
Identification of core targets and pathways mediating the therapeutic effect of Astragalus membranaceus against Lupus Nephritissurrogate

Bioinformatics analysis suggests Astragalus membranaceus may treat lupus nephritis by suppressing inflammation and autophagy via targets like IL-1β, CASP3, STAT1, and PPARγ.

Cite This Study

Liu et al. (2021) studied this question.

synapsesocial.com/papers/6a70f22d3ce530166bc2f8d9https://doi.org/10.21203/rs.3.rs-936493/v1
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