Pyridin‐2(1H)‐ones: A Promising Class of HIV‐1 Non‐nucleoside Reverse Transcriptase Inhibitors

The HIV-1 reverse transcriptase (RT) is an attractive target in the treatment of AIDS. This minireview focuses on the advances in the development of non-nucleoside RT inhibitors of the pyridin-2(1H)-one class. Representative molecules, covering several subclasses are presented. Computational studies, including automated docking and QSAR, are also discussed.