Key result
Statins offer potential neuroprotection during stroke and may prevent dementia onset.
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The beneficial effect of beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) in primary prevention of coronary artery disease in those with hypercholesterolaemia and in secondary prevention in those with established coronary vascular disease are now well known. A growing body of evidence suggests that statins also possess important additional clinical benefits, such as stroke risk reduction. In this article we review the evidence that statins may be neuroprotective, especially in the brain parenchyma during stroke. We also review the observational data that statins may prevent the onset of dementia.
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Sheehy et al. (2001) conducted a review in Stroke and dementia. Statins (HMG-CoA reductase inhibitors) was evaluated on Neuroprotection during stroke and prevention of dementia onset. Statins may provide neuroprotective benefits in the brain parenchyma during stroke and potentially prevent the onset of dementia based on reviewed evidence.
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