Summary The sera of mice immunized with sheep erythrocytes were found to contain two types of macroglobulin anti-sheep erythrocyte antibody. One type fixes complement and is hemolytic; the second type cannot fix complement or lyse red cells except in the presence of rabbit anti-mouse macroglobulin antiserum. The ratio of the non-hemolytic to hemolytic serum antibody increased during the course of the primary response.
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Plötz et al. (1968) studied this question.