The evolutionary significance of genetic variation at enzyme synthesizing loci in the teleost Fundulus heteroclitus

Using the teleost Fundulus heteroclitus as an experimental model, we demonstrate how a multi‐disciplinary approach to problems of intraspecies genetic variation can provide a better understanding of complex biodiversity problems than can be addressed by a more monolithic approach. We emphasize the importance of starting with simple molecular systems and making predictions that can be tested by experimentation at a higher level of biological complexity‐leading from molecules to cells to organ systems to organisms and eventually laboratory and field selection experiments. Using this interdisciplinary approach, we address the classical ‘selectionisti neutralist’ controversy.