Why the study?
The study investigated the clinical factors associated with functional ambulatory outcomes and gender differences in prestroke depressive patients treated with thrombolytic therapy.
There are significant gender disparities in the clinical factors that predict functional ambulatory improvement in prestroke depressive patients treated with thrombolytic therapy.
May guide gender-specific counseling in prestroke depression; leaves open need for prospective validation before practice change.
Aim: This study investigated the clinical factors associated with functional ambulatory outcomes and gender differences in prestroke depressive patients. Materials & methods: Clinical risk factors associated with improved functional outcomes with recombinant tissue plasminogen activator-treated cohorts were determined using binary logistic regression. Results: In the adjusted analysis, improvement in ambulation was associated with male patients that had higher National Institute of Health stroke scale score (p = 0.04), a stroke history (p = 0.026), lower serum creatinine levels (p = 0.049) and were taking cholesterol reducing medication (p = 0.014). Improvement in females was associated with taking antidepressants (p = 0.027) and having lower National Institute of Health stroke scale score (p = 0.002). Conclusion: Our findings indicate gender disparities between male and female prestroke depressive patients.
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Tate et al. (2020) studied this question.
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