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December 1, 1944The Journal of Experimental MedicineOpen Access

The Sedimentation Rate of the Biological Activities of Influenza a Virus

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Authors

MLMax A. LaufferRockefeller FoundationGMGail Lorenz MillerEastern Kentucky University

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Implication

Laboratory study reveals identical sedimentation rates for infectivity and hemagglutination in influenza A preparations, indicating these functions reside on 100-millimicron spherical particles.

Key Points

  • To determine the sedimentation rates of biological activities, including infectivity and red blood cell agglutination, in influenza A virus strains.
  • Evaluated the sedimentation rates of mouse infectivity for influenza A virus strains PR8 and F12 using a separation cell.
  • Assessed chicken red blood cell agglutinating activity and chick embryo infectivity of PR8 preparations in relation to the 100 mµ component and viral aggregates.
  • Sedimentation rates of mouse infectivity for PR8 and F12 strains did not differ significantly from the sedimentation rates of the principal components in purified preparations.
  • The bulk of chicken red blood cell agglutinating activity and chick embryo infectivity in PR8 preparations sedimented at the same rate as the 100 mµ component, with minor activity linked to aggregates.

Cite This Study

Lauffer et al. (1944) studied this question.

synapsesocial.com/papers/6a70fabf84cc45bb7bdfdae5https://doi.org/10.1084/jem.80.6.521
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Also Consider

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  2. 2AN IMPROVED AIR-DRIVEN TYPE OF ULTRACENTRIFUGE FOR MOLECULAR SEDIMENTATION1937 · 52 citations
  3. 3THE MOUSE INFECTIVITY TITRATION OF INFLUENZA VIRUS1944 · 22 citations
  4. 4BIOPHYSICAL PROPERTIES OF PREPARATIONS OF PR8 INFLUENZA VIRUS1944 · 47 citations
  5. 5CENTRIFUGATION AND ULTRAFILTRATION STUDIES ON ALLANTOIC FLUID PREPARATIONS OF INFLUENZA VIRUS1944 · 68 citations