Potassium channel gene mutations rarely cause atrial fibrillation
Why the study?
Are mutations in KCNJ2 and KCNE1-5 a common cause of familial atrial fibrillation?
Population
96 patients with familial atrial fibrillation, mean age 56 years, 81% with paroxysmal atrial fibrillation.
Design
Cohort
Authors
Discussion
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Member takes
Implication
Routine KCNJ2/KCNE1-5 testing has low yield in familial AF; leaves open other genetic contributors in broader cohorts.
Structured PICO
Are mutations in KCNJ2 and KCNE1-5 a common cause of familial atrial fibrillation?
P
Population
96 patients with familial atrial fibrillation (83 with lone atrial fibrillation, 13 with atrial fibrillation and hypertension), mean age 56 years, 81% with paroxysmal atrial fibrillation.
I
Intervention
Genetic screening for mutations in KCNJ2 and KCNE1-5 using automated sequencing
O
Outcome
Detection of mutations in KCNJ2 and KCNE1-5surrogate
Mutations in KCNJ2 and KCNE1-5 are rarely the cause of typical familial atrial fibrillation in a referral clinic population.
Cite This Study
Ellinor et al. (2006) studied this question.