A simple and straightforward method for creating nanoparticle microarrays on poly(ethylene glycol) brushes by using a noncontact microarrayer provides cellular nanoenvironment platforms for high-throughput and high-content cell assays on a single chip. Better transfection efficiency, cell proliferation, and cell survival are observed when cells are assayed on the nanofeatured surface (see image) than when they were assayed on a flat glass surface without nanofeatures.
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Jang et al. (2008) studied this question.
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