Key result
HDL-C shows a U-shaped association with adverse cardiovascular events in population cohorts.
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Reveals a U-shaped association between HDL cholesterol and adverse events in population cohorts, indicating that extremely high levels may not confer cardiovascular protection.
Despite historical evidence suggesting an inverse association between HDL cholesterol (HDL-C) and adverse cardiovascular events, pharmacological efforts to increase HDL-C and improve outcomes have not been successful. Recently, a U-shaped association between HDL-C and adverse events has been demonstrated in several population cohorts, further complicating our understanding of the clinical significance of HDL. Potential explanations for this finding include genetic mutations linked to very high HDL-C, impaired HDL function at high HDL-C levels, and residual confounding. However, our understanding of this association remains premature and needs further investigation.
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Allard‐Ratick et al. (2019) conducted a review in Adverse cardiovascular events. HDL cholesterol (HDL-C) levels was evaluated on Adverse cardiovascular events. High-density lipoprotein cholesterol (HDL-C) exhibits a U-shaped association with adverse events in population cohorts, potentially due to genetics, impaired HDL function, or confounding.
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