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October 21, 2003Circulation

Time-Dependent and Tissue-Specific Accumulation of mtDNA and Respiratory Chain Defects in Chronic Doxorubicin Cardiomyopathy

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Why the study?

Does doxorubicin induce time-dependent and tissue-specific accumulation of mtDNA and respiratory chain defects in rats?

Population

Rats (starting at 11 weeks or 41 weeks of age)

Comparison

Intravenous doxorubicin weekly for 7 weeks, or… vs Saline

Design

Preclinical

Follow-up

Up to 48 weeks of age

Authors

DLDirk LebrechtUniversity of FreiburgBSBernhard SetzerGoethe University FrankfurtUKUwe‐Peter KetelsenUniversity of Freiburg

Discussion

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Overview

Doxorubicin-associated mitochondrial defects in rats support further mechanistic study; leaves open relevance to human cardiotoxicity prevention.

Structured PICO

Does doxorubicin induce time-dependent and tissue-specific accumulation of mtDNA and respiratory chain defects in rats?

P
Population
Rats (starting at 11 weeks or 41 weeks of age)
I
Intervention
Intravenous doxorubicin (1 mg/kg) weekly for 7 weeks, or single injection (6 days or 2 hours before euthanasia)
C
Comparator
Saline
O
Outcome
Development of cardiomyopathy (clinical, macroscopic, histological, and ultrastructural), mitochondrial DNA (mtDNA) alterations, and respiratory chain dysfunctionsurrogate

Doxorubicin-induced cardiomyopathy is associated with long-term, time-dependent accumulation of mtDNA alterations and respiratory chain dysfunction even after drug cessation.

Cite This Study

Lebrecht et al. (2003) studied this question.

synapsesocial.com/papers/6a70fe6aa2d7cf2e39c2bd00https://doi.org/10.1161/01.cir.0000093196.59829.df
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Also Consider

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