Why the study?
Does nonpulsatile systemic circulation alter sympathetic nerve activity compared to pulsatile circulation in anesthetized goats?
Population
Anesthetized goats
Comparison
Nonpulsatile systemic circulation vs Pulsatile systemic circulation
Design
Preclinical
Authors
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May indicate sympathetic activation with nonpulsatile flow; hypothesis-generating for human MCS implications.
Does nonpulsatile systemic circulation alter sympathetic nerve activity compared to pulsatile circulation in anesthetized goats?
Depulsation of systemic circulation significantly increases mean renal nerve activity and alters its rhythm in an animal model, which may have physiological implications for nonpulsatile mechanical circulatory support.
Toda et al. (1996) studied this question.
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