Utilization and Outcome of High-Frequency Oscillatory Ventilation in Neonates and Premature Infants; Systematic Review

Study Aim:The study aim to compare HFOV with alternative breathing techniques in terms of clinical outcomes, complications, and long-term impacts, and to evaluate the effectiveness of HFOV in enhancing oxygenation, ventilation duration, and neonatal survival rates.Method: The PRISMA guideline was followed in the course of our investigation.We looked for publications published between 2012 and 2024 using the electronic databases PubMed, Cochrane, and Scopus.Our search targeted cohort studies and randomized controlled trials; studies that evaluate various neonatal breathing techniques; studies that use quantitative outcome measures; and studies involving newborns with respiratory distress syndromes.We exclude studies involving older infants, children, or adults, case reports, editorials, expert comments, narrative reviews, studies that do not employ HFOV as the major intervention, and studies that do not compare HFOV to another ventilation method. Result and Discussion:In newborns with severe respiratory distress, HFOV is a successful but not selective breathing technique that offers benefits in lung preservation and oxygenation; nevertheless, its impact on survival and long-term results is still up for discussion.Early initiation, usage in certain patients, and combination with other supportive therapies (surfactant therapy) result in improved outcomes for HFOV.Long-term follow-up research and randomized controlled trials are advised to enhance HFOV procedures, reduce complications, and improve neonate outcomes in general.