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December 21, 1999Chemical Research in Toxicology

Synthesis and Reactivity of a Potential Carcinogenic Metabolite of Tamoxifen:  3,4-Dihydroxytamoxifen-o-quinone

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Authors

FZFagen ZhangYibin UniversityPFPeter W. FanMerck & Co., Inc., Rahway, NJ, USA (United States)XLXuemei LiuJiangsu University

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Zhang et al. (1999) studied this question.

synapsesocial.com/papers/6a71001d26a7f98052dd6ff0https://doi.org/10.1021/tx990145n
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Semiquinone anion radicals from addition of amino acids, peptides, and proteins to quinones derived from oxidation of catechols and catecholamines. An ESR spin stabilization study.1987 · 156 citations
  2. 2Hard acid and soft nucleophile system. 2. Demethylation of methyl ethers of alcohol and phenol with an aluminum halide-thiol system1980 · 151 citations
  3. 3Regiospecific attack of nitrogen and sulfur nucleophiles on quinones derived from poison oak/ivy catechols (urushiols) and analogs as models for urushiol-protein conjugate formation1981 · 75 citations
  4. 4DNA fragmentation during exposure of rat cerebella to ethanol under hypoxia imposedin vitro1999 · 20 citations
  5. 5Tamoxifen-associated eye disease. A review.1996 · 177 citations