December 26, 2007PLoS ONEOpen Access

A Tale of Switched Functions: From Cyclooxygenase Inhibition to M-Channel Modulation in New Diphenylamine Derivatives

View Full Paper

Ask AI

Bookmark

Population

Transfected CHO cells, sensory dorsal root ganglion and hippocampal neurons, and mice

Design

Preclinical

Authors

APAsher PeretzTel Aviv University NDNurit Degani-KatzavBar-Ilan University TMTalmon Maya

Discussion

Member takes

Implication

Hypothesis-generating for selective M-channel modulators without COX effects; leaves open translation to human epilepsy therapy.

Structured PICO

Population

Transfected CHO cells, sensory dorsal root ganglion and hippocampal neurons, and mice (maximal electroshock seizure model)

Intervention

New derivatives of diphenylamine carboxylate (amides or esters linked to various alkyl and ether chains)

Outcome

Activation of recombinant Kv7.2/3 K(+) channels, membrane potential hyperpolarization, depression of evoked spike discharges, and anti-convulsant activitysurrogate

New diphenylamine derivatives successfully dissociate M-channel modulation from COX inhibition, providing a structural framework for novel M-channel modulators with anti-convulsant activity.

Cite This Study

Peretz et al. (2007) studied this question.

synapsesocial.com/papers/6a7100e9e71d69abee08fcf3 https://doi.org/10.1371/journal.pone.0001332

View Full Paper

Ask AI

Bookmark

A Tale of Switched Functions: From Cyclooxygenase Inhibition to M-Channel Modulation in New Diphenylamine Derivatives

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Tale of Switched Functions: From Cyclooxygenase Inhibition to M-Channel Modulation in New Diphenylamine Derivatives

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider