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May 18, 2005Journal of NeuroscienceOpen Access

Molecular Determinants of KCNQ (Kv7) K+Channel Sensitivity to the Anticonvulsant Retigabine

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Population

KCNQ (Kv7) K+ channels (KCNQ1-5) and constructed chimeras

Design

Preclinical

Authors

ASAnne SchenzerTFThomas FriedrichMPMichael Pusch

Discussion

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Overview

May inform KCNQ modulator design; leaves open clinical translation from animal data.

Structured PICO

P
Population
KCNQ (Kv7) K+ channels (KCNQ1-5) and constructed chimeras
I
Intervention
Retigabine
O
Outcome
Sensitivity to retigabine and identification of minimal segments required for drug sensitivitysurrogate

A specific tryptophan residue in the S5 segment of KCNQ2-5 channels is essential for their sensitivity to the anticonvulsant retigabine.

Cite This Study

Schenzer et al. (2005) studied this question.

synapsesocial.com/papers/6a7100e9e71d69abee08fcf5https://doi.org/10.1523/jneurosci.0128-05.2005
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