Why the study?
Do angiotensin receptor subtypes play a role in angiotensin clearance from plasma in rats?
Population
Intact and nephrectomized (anephric) rats
Comparison
Type 1 angiotensin II receptor antagonist or… vs Absence of receptor inhibition
Design
Preclinical
Authors
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Challenges assumption of AT1/AT2 as angiotensin clearance receptors; leaves open alternative renal mechanisms and human relevance.
Do angiotensin receptor subtypes play a role in angiotensin clearance from plasma in rats?
The findings argue against type 1 or 2 angiotensin II receptors acting as clearance receptors, suggesting instead an alternative renal mechanism for altered angiotensin clearance by selective type 2 ligands.
Vernace et al. (1994) studied this question.